Endocrine Abstracts

Introduction: Microalbuminuria is known as a predictor of cardiovascular disease (CVD) in patients with and without diabetes, as well as the general population. The objective was to determine whether there was an association between the urinary albumin excretion and CVD risk by estimating the Framingham Risk Score (FRS) in nondiabetic middle-aged adults.Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey,...

Thyroid cancer is one of the common head and neck malignancies and may be found incidentally with other head and neck cancers. The purpose is to evaluate the prevalence and risk of malignancy in incidental thyroid lesions identified by ultrasound (US) in patients with head and neck cancer. We retrospectively reviewed medical records of all patients with head and neck cancer other than of thyroid origin between January 2004 and January 2012. A total of 697 patients (542 men and...

Runx2 and Osterix(Osx) have been known as the master transcription factors for bone formation. However, genes that act downstream of both Runx2 and Osx have not been fully studied. To investigate downstream target genes of Runx2 and Osx, DNA microarray was conducted in calvaria of WT, Runx2ΔC/+, Osx+/−, and Runx2ΔC/+; Osx+/− double heterozygous mice designated WT, Runx2het, Osxhet, and Doub...

Objective: Despite beneficial effect of FGF-21 on metabolic disease, there were concerns about adverse effect on bone metabolism, supported by animal studies. However, a recent human study showed the positive association between FGF-21 and bone mineral density (BMD) in health premenopausal women. This study was undertaken to examine the association between FGF-21 and BMD in healthy postmenopausal Korean women who are susceptible to osteoporosis.<p class="a...

Objective: Dipeptidyl peptidase (DPP)-4 is highly abundant in the kidney. In various chronic inflammatory diseases, soluble DPP-4 activity is used as a marker for diabetes, coronary artery disease and cancer. This study examined the association between serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus.Research design and methods: Soluble DPP-4 activities were measured retrospectively in a total...

Background/objectives: This study aimed to investigate associations between self-reported sleep duration and general and abdominal obesity in Korean adults stratified according to sex and age.Subjects/methods: Data from 41,805 adults, 18–110 years of age, collected by the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007 and 2015, were included. Obesity was defined as body mass index (BMI) ≥25 kg/m2, and abdo...

Thyroid nodules were frequently incidentally discovered during radiologic studies of chest or neck. We investigated the prevalence and clinical importance of thyroid incidentaloma during carotid artery ultrasonography in patients with diabetes. We retrospectively reviewed the data of enrolling all diabetic patients who were performed carotid artery ultrasonography at the Diabetes Center of Wonju Severance Christian Hospital from January to December 2013. Chart reviews of all e...

Background/Objectives: Although it has been well-established that menopause causes a shift in body fat, thereby eliciting metabolic disturbances in women, there has been no study conducted yet to examine the best obesity parameters to predict the risk of nonalcoholic fatty liver disease (NAFLD) in this population. Thus, the aim of this study was to compare the efficacy of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) for screening NAFLD accordin...

Background: The 2015 ATA guidelines recommend total thyroidectomy with therapeutic central lymph node dissection (CND) for papillary thyroid carcinoma (PTC) patients with clinical central lymph node metastasis (CLNM). The purpose of this study is to verify that total thyroidectomy with therapeutic bilateral CND is necessary for all patients with unilateral cN1a PTC.Methods: This study retrospectively reviewed 899 PTC patients who had total thyroidectomy ...

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into various types of cells including chondrocytes, osteoblasts and adipocytes. Since these types of cells are simultaneously derived from the same precursor cell, adipogenesis and osteoblastogenesis are thought to be counter-related. It is well-known that chronic treatment of steroid can induce Cushing’s syndrome which has phenotypes like visceral adiposity and osteoporosis. Cell fate of d...